Finally, academic literature projects with similar designs but using other drugs have been published; for example, “Sequential nephron blockade versus sequential renin-angiotensin system blockade in resistant hypertension: a prospective, randomized, open, blinded-endpoint study” [46]; and “True antihypertensive efficacy of sequential nephron blockade in patients with resistant hypertension and confirmed medication adherence” [47]. This evidence concerns the gene REN and Hypertension resistant to conventional therapy.