Our results identified 5 up-regulated pathways (including Primary immunodeficiency, Glioma, Melanoma, Bile secretion, Cell cycle signaling pathways) (Fig. 3) and 14 down-regulated pathways (including ECM-receptor interaction, focal adhesion, Regulation of actin cytoskeleton, Proteoglycans in cancer, TGF-beta signaling pathway, Cell adhesion molecules and PI3K-Akt signaling pathways) (Fig. 4). Here, AKT1 is linked to central nervous system cancer.