In contrast to our findings, the SNP rs3218536 (also known as Arg188His in exon 3 of the XRCC2 gene), acting individually was reported to be associated with a slightly protective effect for breast cancer in a study of 1100 Cypriot women [OR = 0.79; 95% CI = 0.62–1.00; P = 0.05] [6]. This evidence concerns the gene XRCC2 and breast cancer.