Four SNPs showed significant association with breast cancer:rs3218550, NC_000007.14:g.152646870C > T,NG_027988.1:g.34296G > A,NM_005431.1:c.*1772G > A [X-ray repair cross-complementing gene-2 (XRCC2)/7q36.1]; rs6917,NC_000017.11:g.49404181G > A,NG_023046.1:g.15700C > T,NM_001281496.1:c.*811C > T [prohibitin-1 gene (PHB)/17q21.33]; rs1801516,NC_000011.9:g.108175462G > A,NG_009830.1:g.86904G > A,NM_000051.3:c. This evidence concerns the gene PHB1 and breast cancer.