In the T2DM patients, the 6-month retrospective and 4-week prospective data, respectively, were: the percentage of patients who consulted their doctor or nurse (39.3% vs. 32.6%), required any form of medical assistance (41.0% vs. 32.6%), increased calorie intake (27.6% vs. 17.6%), avoided physical exercise (11.3% vs. 9.2%), reduced insulin dose (18.8% vs. 13.0%), skipped insulin injections (18.0% vs. 9.8%), and increased blood glucose monitoring (28.9% vs. 20.9%). The gene discussed is INS; the disease is type 2 diabetes mellitus.