Further, we detected relatively lower expression of TGF-β2, TGF-βRIII, ARHGEF15 and ABL2 in both SW1990- and PANC-1-reporter cells co-cultured with irradiated feeder cells than those with untreated ones in vitro (Fig. 4h), and similarly in irradiated tumor tissues than in the untreated ones in vivo (Fig. 4i). The gene discussed is ARHGEF15; the disease is neoplasm.