For example, functional expression of TRPV4 in retinal microvascular ECs are reduced in hyperglycemia and diabetes [9]; activation of TRPV4 in retinal ganglion cells leads to glaucoma and retinal detachment [29]; and TRPV4 is a target for treating ocular hypertension and conventional outflow by regulating Ca2+ homeostasis and cytoskeletal remodeling [30]. This evidence concerns the gene TRPV4 and diabetes mellitus.