We found that each cell specific predictors served as good prognostic markers for early stage breast cancer patients (Fig. 7, ER+ predictors with p-value 4.2 × 10− 6, HER2+ predictors with p-value 1.1 × 10− 5, TNBC predictors with p-value 9.03 × 10− 8). This evidence concerns the gene ESR1 and breast cancer.