A targeted liposome (LP) delivery system with dual moieties, arginine-glycine-aspartic acid peptide (RGD) and Tf to deliver Paclitaxel (PTX) for glioma therapy is successfully relevant, reinforcing the use of dual functionalities where the authors showed greatest antitumor effects in vivo for the PTX-loaded RGD/TF-LP (Qin et al., 2014). Here, TF is linked to central nervous system cancer.