A time-dependent (1 and 4 h) study showed the geometric means for TfL, R8L and DualL were 2.8 ± 0.1, 7.3 ± 0.3 and 23.3 ± 9.4 after 1 h, respectively, while after 4 h the means were 4.8 ± 0.2, 28.1 ± 4.4 and 58.5 ± 12.9, respectively in A2780 cells, indicating a two-fold higher cell association was for DualL compared to R8L at 4 h exposures in cancer cells (Figure 2(a)). The gene discussed is ZC3H12D; the disease is cancer.