Having observed increased apoptotic activity in both Drosophila and mammalian models of CHMP2BIntron5 FTD, and taking into account the role of POSH as a pro-apoptotic JNK scaffold, we asked whether these models showed elevated JNK signaling and whether this could be alleviated by inhibition of POSH. Here, MAPK8 is linked to frontotemporal dementia.