Our observation that the pro-apoptotic JNK scaffold POSH aberrantly accumulates in both Drosophila and mammalian models of CHMP2BIntron5 FTD and that POSH knockdown alleviates aberrant neuronal phenotypes identifies it as a potentially novel pro-apoptotic factor in FTD pathology. This evidence concerns the gene MAPK8 and frontotemporal dementia.