Contrarily, we observed no influence of saturating concentrations of EphA2-Fc/EphB3-Fc on the infection with Eph-binding-negative mutants KSHV gH-ELAAN, RRV gH-AELAAN or RRV ΔgL when compared to infection with untreated or soluble Fc treated viral inocula (Fig 5A and 5B). Here, EPHB3 is linked to infection.