For example, Kouhkan et al reported that miR‐129‐1 acted as a suppressor in glioblastoma cells through targeting IGF2BP3 and MAPK114 and miR‐129‐2 targeting HMGB1 was reported by Yang et al15 Xu et al also reported that miR‐129‐5p inhibited glioblastoma cell viability and metastasis by targeting FNDC3B. 9 Despite the antecedent studies, researches on the specific mechanism of miR‐129‐5p regulation in glioma cells are still insufficient. Here, HMGB1 is linked to glioblastoma.