On the other hand, accumulating evidence showed that the regulatory mechanisms of some mRNAs in certain cancers were associated with TGIF2, such as miR‐541‐3p in non‐small cell lung cancer,16 miR‐148a in skin cancer 18 and miR‐34a in gastric cancer.19 Generally, TGIF2 was found up‐regulated in these tumours and acted as an antagonist of relative tumour‐suppressing miRNAs.16, 18, 19 But the correlation between TGIF2 and miR‐129‐5p still remains unknown. Here, TGIF2 is linked to skin cancer.