To explicate the specific regulatory mechanism of miR‐129‐5p in glioma cell progression, Xu et al identified its targeting gene FNDC3B, while we centred on the interaction between miR‐129‐5p and another targeting gene TGIF2. Previous studies had also revealed that TGIF2 could be targeted and regulated by various mRNAs in different cancers. The gene discussed is TGIF2; the disease is central nervous system cancer.