This initial observation was followed up by a series of reports supporting the hypothesis,32, 33, 34 though it has however been challenged in recent years.35, 36, 37 Our results indicate that it is unlikely that PKA can explain the observed increased in spontaneous Ca2+ release events, given that pPLB Ser‐16 (which is the PKA phosphosite of PLB) was almost undetectable in biopsies from MI patients. Here, PLN is linked to myocardial infarction.