Of note, among functional categories involved in ALS/neurodegeneration such as lipid metabolism process [52], regulation of actin cytoskeleton organization [53], protein transport [54], and DNA repair [55], we identified a cluster of genes named “Ion Transport.” It included Gria2, which was predicted to be targeted by miR-409-3p, miR-495-3p, and miR-375-3p at multiple sites. Here, GRIA2 is linked to amyotrophic lateral sclerosis.