Among these, there is a cluster (amyotrophic lateral sclerosis) composed of 12 genes linked to ALS through different pathogenic mechanisms such as protein misfolding/ER stress (Derlin1), MAPK signaling (Ask1, p38), mitochondrial pathway of cell death (Bcl-2, Bcl-2l1, Apaf1), and Ca2+ dysregulation (calcineurin). Here, APAF1 is linked to amyotrophic lateral sclerosis.