GRIA2 and amyotrophic lateral sclerosis: Moreover, in the case of Gria2, a subunit of the glutamate AMPA receptor already linked to MN physiology and ALS pathogenesis, we have identified a specific negative regulatory loop (i) mediated by the upregulation of miR-409-3p and miR-495-3p and (ii) reinforced by the altered nucleus/cytoplasmic partitioning of FUS-P517L.