Controversial data regarding treatment of this syndrome indicates how necessary are further studies to elucidate the intricacies within the pathophysiology of PCOS and the true relationship between IR, hyperinsulinemia, and hyperandrogenemia, as well as other important hormonal disturbances, alterations in steroid hormone metabolism, hyperleptinemia, and LEP resistance [23]. Here, LEP is linked to Hyperinsulinemia.