IFNG and infection: Other granzymes, such as GzmD and GzmK, were also upregulated in both strains. Ifn-γ (interferon gamma) was activated during the later stage of infection, with a 24.2-fold increase in BALB/c mice (BALB/c 10 dpi versus BALB/c uninfected) and a 5.2-fold increase in C57BL/6 mice (C57BL/6 10 dpi versus C57BL/6 uninfected).