IFN-ζ and IFN-α2 were upregulated in C57BL/6 mice but not in BALB/c mice, and this was true for GzmA and IL1F9 expression. GzmB was strongly upregulated in both mouse strains at the late stage of viral infection, while other members (GzmC, GzmD, GzmE, and GzmF) were upregulated only in BALB/c mice at 10 dpi. This evidence concerns the gene IL36G and viral infectious disease.