TNFSF13B and systemic lupus erythematosus: In the last decade, B cell depleting antibodies such as anti-CD20 (e.g. Rituximab, Ocrelizumab, Ofatumumab) and drugs that inhibit B cell activating factors (e.g. Belimumab, BLyS inhibition; Atacicept, BLyS/APRIL inhibition) have been introduced as new therapies for SLE patients [5] (see Figure 1 for overview of current therapeutic targets).