IL6 and systemic lupus erythematosus: Despite these pre-clinical results, a small, short-term phase II clinical trial testing the effect of anti-IL-6 monoclonal antibodies (PF-04236921) in SLE patients did not meet the primary endpoints; although several parameters, including levels of anti-dsDNA autoantibodies and disease flares, were reduced in patients treated with a low-dose of antibody [46].