In fact, NOX2 is also expressed in endothelial cells [18], cardiomyocytes [19], hematopoietic stem cells (HSC) [20, 21], and platelets [22] and its upregulation has been shown to be involved in neurodegenerative disease [23], neoplasms [24], and cardiovascular diseases [25–28]. Here, CYBB is linked to neurodegenerative disease.