Autoinflammatory and autoimmune disorders have been identified in patients with CGD, female carriers for NOX2 deficiency, and patients carrying oxidase gene polymorphisms, suggesting a role for NADPH oxidase in the pathogenesis of autoimmunity and in the in regulation of the adaptive immune responses [187–189]. The gene discussed is CYBB; the disease is hyperinsulinemic hypoglycemia, familial, 4.