MTOR and chronic granulomatous disease: Furthermore, it has been observed that in both human and murine models of CGD macrophages, which explain a permissive phenotype for bacterial replication, autophagy induction by rapamycin, a mammalian target of rapamycin (mTOR) inhibitor, is able to reduce B. cenocepacia bacterial burden, suggesting that the increase of the autophagic flux may represent a potential therapeutic approach to improve bacterial clearance in CGD [219].