ERN1 and central nervous system cancer: On the contrary, while inhibition of IRE1 in malignant glioma correlates with the downregulation of proangiogenic factors such as VEGF-A, IL-1β, IL-6, and IL-8, it induces a significant upregulation of proteins linked to mesenchymal differentiation and glioma invasiveness such as SPARC, decorin, and thrombospondin-1, demonstrating that IRE1 in malignant glioma promotes the formation of functional tumor blood vessels and attenuates tumor cell invasion as well as vessel cooption [205, 206].