A meta-analysis performed by the Emerging Risk Factors Collaboration has also shown that higher plasma IL-6 concentrations predict the risk of nonfatal myocardial infarction and coronary artery disease-related death, with a 25% increase in the risk of future vascular events for each increase in log IL-6 concentrations (RR 1.25, 95% CI 1.19 to 1.32) [63]. This evidence concerns the gene IL6 and coronary artery disorder.