Even though we were able to confirm the interesting relationship between atherosclerotic lesions in the arteries of the lower extremities, obesity as well as selected aPLs and IL-23 levels in lupus patients also suggests the possible contribution of this cytokine in vascular involvement in the course of SLE, revealing new insights into atherothrombotic risk assessment in SLE patients. The gene discussed is IL37; the disease is systemic lupus erythematosus.