The analysis of the role of selected proinflammatory and angiogenic cytokines in SpA patients [14, 15, 32, 33] showed higher levels of IL-23 in ankylosing spondylitis in comparison with the controls and revealed the association with selected clinical characteristics such as psoriatic onycholysis and the use of nonsteroid anti-inflammatory drugs [14, 15]. The gene discussed is IL37; the disease is ankylosing spondylitis.