In the multivariate stepwise analysis, the OR for serum levels of IL-23 > 3.1 pg/mL in SLE patients with atherosclerotic plaque in the right common femoral artery was 4.27 (95% CI 1.08–16.89), P = 0.038, with obesity was 4.21 (95% CI 1.40–12.67), P = 0.011, and with the presence of aSS-B/La was 4.14 (95% CI 1.14–15.07), P = 0.031 (Table 8). The gene discussed is IL37; the disease is obesity due to melanocortin 4 receptor deficiency.