Because tumor cells require abnormally high levels of transcription for their inappropriate proliferation and survival, increased overall transcription mediated by ZFX may explain why this TF has been correlated with poor prognosis for a variety of human cancers (Jiang and Liu 2015; Li et al. 2015; Yang et al. 2015; Yan et al. 2016). The gene discussed is TF; the disease is cancer.