NPHS1 and Alport syndrome: These genetic diseases include congenital nephrotic syndrome (nephrin and podicin; Hildebrandt, 2010), Alport syndrome (collagen genes, including COL4A3; Lemmink et al., 1994), Pierson syndrome (LAMB2; Zenker et al., 2004), and Frasier syndrome (WT1; Barbaux et al., 1995).