Similar to Ptgs1/Ptgs2−/− BRAFV600E tumors, B16-OVA tumors (that do not produce PGE2) (Zelenay et al., 2015) expressing CCL5 and XCL1 showed increased accumulation of cDC1 within the TME (Figure 5G) and decreased tumor growth (Figure 5H). The gene discussed is PTGS1; the disease is neoplasm.