XCL1 and neoplasm: The observed clustering of cDC1 and NK cells within the TME might ensure further communication between these two cell types, eventually leading to mutual activation of cDC1 and NK cells and facilitating anti-tumor immunity, similar to reciprocal activation of cDC1 and XCL1-secreting T cells in lymph nodes and within the intestine (Brewitz et al., 2017, Ohta et al., 2016).