In addition to these DAMPs and PAMPs, a recent study has shown that hepatocyte-derived histidine rich glycoproteins (HRG) can promote M1 responses in Mφs in vitro and that HRG-/- mice display attenuated liver injury and fibrosis on the methionine-choline deficient diet (MCDD), a murine model of NASH [177]. The gene discussed is HRG; the disease is fibrosis.