Ly6Chi monocytes have been shown to be the main contributors to the Mφ pool [210], however, the development of atherosclerosis is only halted when recruitment of both monocyte subsets (Ly6Chi and Ly6Clo) is abolished through the inhibition of CCR5, CX3CR1 and CCL2 in the Apoe-/- model [119], [211]. This evidence concerns the gene APOE and atherosclerosis.