Interestingly, LRRK2-PD variants are characterized by defects in microtubule associated processes [68] and LRRK2 regulates microtubule stability [69].However, extension and navigation of neurites are normally driven by actin-rich growth cones and inhibition of microtubules dynamics does not stop neurite outgrowth [66]. Here, LRRK2 is linked to Parkinson disease.