Conflicting reports exist regarding the influence of IDH1 mutation on global levels of 5hmC in gliomas, and to date no quantitative genome-wide locus-specific interrogation of 5hmC status in IDH1 mutant (IDH1 mt) tumors has been published to our knowledge [15, 16, 26, 28, 32, 33, 39, 48, 53, 67, 75, 78]. This evidence concerns the gene IDH1 and central nervous system cancer.