MYD88 and infection: TLR4 expression in neurons of traumatic encephalopathy patients has also been reported to increase at early infection and decrease at late infection, and TLR4 is thought to play a vital role in inflammatory responses involving MyD88/NF-κB activation and initiate the TLR4/MyD88/NF-κB signaling pathway [26, 37], suggesting that TLR4 is very important for the ability of RSV to infect neuronal cells.