Our aims were to: (1) characterise PLA2 gene expression and its related isoforms in adipose tissue; (2) determine the depot-specific expression within adipose tissue and the impact of obesity and type 2 diabetes; (3) define how cardiometabolic risk factors are associated with circulating Lp-PLA2 levels within different metabolic states; and (4) evaluate the molecular impact of LDL-cholesterol and oxLDL on Lp-PLA2 expression within adipocytes. The gene discussed is PLA2G1B; the disease is obesity due to melanocortin 4 receptor deficiency.