Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 superfamily of enzymes, which promote the formation of oxidised LDL (oxLDL), a producer of proinflammatory mediators such as lysophosphatidylcholine and oxidised fatty acids (enhanced in states of metabolic disease) [1, 2]. This evidence concerns the gene PLA2G7 and metabolic disease.