Notably, 15 aggregating proteins after ischemic stroke were RNABPs linked to ALS and FTD, among them TDP43 and hnRNPA18,17, as well as PSF/SFPQ and p54/NONO, two paraspeckle proteins with emerging roles in ALS18,19. The gene discussed is PFN1; the disease is amyotrophic lateral sclerosis.