Furthermore, TRIM56(+) cGAS(−), TRIM56(−) cGAS(+), and TRIM56(−) cGAS(−) cells failed to induce IP-10 mRNA expression upon HSV-1ΔICP34.5 infection, whereas wild-type (WT) L929 cells were capable of inducing IP-10 mRNA expression upon HSV-1ΔICP34.5 infection (Supplementary Fig. 1c). This evidence concerns the gene TRIM56 and infection.