MUC16 and metastatic malignant neoplasm in the lymph nodes: In order to determine whether these biomarkers are associated with pathological parameters of CRC, we further assessed corrections between CRC pathological parameters (i.e., lymph node metastasis, vascular invasion, etc.)with CEA, CA19-9, CA72-4, CA125 and SF (Table 2) as following:Chi-square test results showed that the preoperative serum CEA expression was significantly different in the presence or absence of lymph node metastasis, nerve infiltration, or pathological tumor-node-metastasis (pTNM) staging (p < 0.05).