Genes in this group include Calreticulin (Calr), which inhibits the binding of Ar and other nuclear receptors to their binding sites in DNA40,41; acetyl-CoA carboxylase (Acaca), which is rate limiting for fatty acid synthesis42; arrestin-1 (Arrb1), which is interesting because it may promote tumor survival by metabolic reprogramming to rely on glycolysis, rather than on oxidative phosphorylation, the former favoring the frequently encountered hypoxic tumor environment43; and annexin-6 (Anx6), which is over-expressed in aggressive pancreatic cancer. The gene discussed is SAG; the disease is familial pancreatic carcinoma.