In this dataset, we observed a gradual increase of GMPR and a gradual decrease of WIF1 from healthy individuals to severe AD cases (Fig. 2C), and the expression alteration was highly correlated with MMSE and NFT values (Table S3, p-value ≤ 0.036), demonstrating that the two genes can be good indicators for AD progression. Here, WIF1 is linked to Alzheimer disease.