Relevant studies have shown that overexpression of ZFP36 inhibited the growth of MDA-MB-231 breast cancer cells but did not cause apoptosis38; however, overexpression of ZFP36L2 also inhibited cell growth but activated apoptosis (e.g., activation of caspase-3 and poly(ADP ribose) polymerase cleavage) in HeLa cells39. This evidence concerns the gene CASP3 and breast cancer.