In light of the promising results of proof-of-concept experiments in subjects with elevated body weight9,13, this mechanism of action may still be functional in obesity, which has been reported to be associated with alterations in circulating oxytocin concentrations40–42, and open up new avenues to normalize eating behaviour in the clinical context43,44. The gene discussed is OXT; the disease is obesity due to melanocortin 4 receptor deficiency.