PARP1 and cancer: The collection of benzimidazole derivatives used in this study have previously been tested for their inhibitory effect on poly (ADP-ribose) polymerase-1 (PARP-1) and dihydroorotate dehydrogenase (DHODH) and a number of these compounds showed promising anti-PARP-1 and DHODH effects, suggesting their prospective role in anti-cancer therapy44.