In patients underwent cardiac surgery, the CD14 rs2569190 GG carriers had higher risk of death related to septic shock during the first 60 days [aHR = 2.26 (95%CI = 1.08; 4.82); p = 0.029] and 90 days [aHR = 2.07 (95%CI = 1.01; 4.29); p = 0.049] than CD14 rs2569190 AA/AG carrier; whereas CD14 rs2569190 GG carriers who underwent abdominal surgery did not have any significant association with mortality related to septic shock during the first 28, 60 and 90 days after diagnosis. The gene discussed is CD14; the disease is Shock.