In 539 patients, the percentage of patients with positive RHBDD1 expression is higher (P < 0.001) among those with lymphatic metastasis than patients without lymphatic metastasis (Table 1), and the intensity score of RHBDD1 is also significantly higher (P < 0.001) in patients with lymphatic metastasis (Fig. 1a). This evidence concerns the gene RHBDD1 and Lymphatic Metastasis.