In a recent study, hypermethylation of p16/Ink4a and p19/Arf followed by gene-silencing and loss of p16 and p19 proteins in mesothelioma are noted after intra-peritoneal injection to mesothelioma-inducing CNT and asbestos Chernova et al. [15]. The gene discussed is CDKN2A; the disease is mesothelioma.