Also in logistic regression analyses, cardiac dysfunction was not associated with the incidence of AKI neither in univariate (OR 0.7, 95% CI 0.33 – 1.51, p = 0.4), nor in multivariate modelling (OR 0.70, 95% CI 0.31 – 1.57, p = 0.4) controlling for COMT genotype and also including the interaction of COMT genotype and cardiac dysfunction. This evidence concerns the gene COMT and acute kidney injury.