Given the reported correlation between CYP4AF2 rs2108622 and 20-HETE [36], functional CYP4AF2 rs2108622 may mediate the nonsynonymous mutation of a valine (V) located at residue 433 to a methionine (M), namely, V433 M, which then leads to the alteration of CYP4F2 protein function and 20-HETE synthesis, thereby influencing the occurrence of coronary heart disease. This evidence concerns the gene CYP4F2 and coronary artery disorder.