CYP17A1 and essential hypertension: For example, GWAS (genome-wide association studies) data show that some SNPs, such as rs1004467 of the CYP17A1 (Cytochrome P450 Family 17 Subfamily A Member 1) gene or rs2681492 of the ATP2B1 (ATPase Plasma Membrane Ca2+ Transporting 1) gene, are associated with susceptibility to blood pressure or essential hypertension [6, 7].