It has been largely demonstrated that among different subtypes of nAChRs, the homomeric pentamer α7-nAChR, composed of five α7-subunits symmetrically arranged around a central ion pore, are responsible for cell growth and tumor progression as well as cell death in NSCLC (Cesario et al., 2012; Zhang et al., 2016). Here, CHRNA7 is linked to non-small cell lung carcinoma.