UGT1A6 and colorectal carcinoma: In the meta-analysis, SNP rs2070959 in the UGT1A6 gene showed evidence of an interaction between aspirin-only use and CRC risk (Pinteraction = 0.01, I2 = 0), whereby aspirin users with wild-type genotype were associated with 23% lower CRC risk (OR = 0.77, 95% CI = 0.69–0.86) compared to negligible risk reduction in variant allele carriers (OR = 0.92, 95% CI = 0.86–0.99) (Fig 1; S11 and S12 Tables).