Meta-analysis of the datasets showed a reduced risk of CRC associated with the presence of variant allele of SNPs rs6983267 (OR = 0.86, 95% CI = 0.79–0.94, P = 0.001, I2 = 0), rs2302615 (OR = 0.85, 95% CI = 0.74–0.98, P = 0.02, I2 = 0) and rs11694911 (OR = 0.85, 95% CI = 0.74–0.96, P = 0.01, I2 = 0) at CCAT2 and the ODC1 gene locus, respectively (S7 Table). This evidence concerns the gene CCAT2 and colorectal carcinoma.