Previously, the ALDH2 polymorphisms have been implied to be related to Alzheimer’s disease [66] which implied an association between ALDH2 polymorphisms and memory system; however, in an older Korean community, Kim et al. (2004) [67] found no significant association between ALDH2 polymorphisms and cognitive outcome, using Mini Mental State Examination (MMSE). This evidence concerns the gene ALDH2 and Alzheimer disease.