KNG1 and alkaline phosphatase measurement: 2016; Gryshchenko et al. 2016; Jakubowska et al. 2016). Specifically, our new data indicate initial roles for BK, followed by trypsin, generating Ca2+ signals in PSCs (Fig. 8) and provide fresh evidence in favour of the propositions made many years ago, but largely ignored, that inhibition of BK receptors could have benefits in the treatment of AP (Griesbacher et al. 1993; Hirata et al. 2002).