As shown in Fig. 5A and B, no difference in tumour volume was observed among the shRNA‐HSP27, the overexpression‐HSP27 and control groups in the first three weeks, but the growth of tumour significantly slowed down in the shRNA‐HSP27 compared with the shRNA‐neg group and the growth of tumour obviously speed up in the HSP27 compared with the EV group since the 4th week. This evidence concerns the gene HSPB1 and neoplasm.