Combination of isolation rearing with an additional developmental ‘hit’ (such as maternal immune activation or neonatal PCP administration [112, 113]) may induce a more complete spectrum of changes relevant to schizophrenia, including deficits in social cognition, and future work will evaluate the effect of 5-HT6 receptor antagonists and specific JNK pathway modulators in such models. Here, MAPK8 is linked to schizophrenia.