In addition, a few studied have been done to investigate anti-cancer activity as well as the underlying mechanisms of PF, which showed that PF could inhibit some tumor types though inducing apoptosis, cell cycle arresting involving multiple signaling molecules like NF-kB, stat3, Notch1 or p53 pathway [15, 38, 39]. The gene discussed is NFKB1; the disease is neoplasm.