TGFβ, as a multifunctional cytokine that has been demonstrated as a regulator in glioblastoma initiation and progression because of its effects on tumor invasion, cell proliferation, angiogenesis, immunosuppression and the maintenance of stemness of glioblastoma stem cells (GSCs) [29, 36, 51]. Here, TGFB1 is linked to glioblastoma.