SRPX2 and amyotrophic lateral sclerosis: Indeed, the differential expression or deficiency in CBPs in neurons has been suggested to be the key reason for the neuronal vulnerability to the progress of pathophysiological conditions associated with motoneuron degenerative diseases such as amyotrophic lateral sclerosis (ALS) (Ince et al. 1993; Alexianu et al. 1994; Elliott and Snider 1995; Reiner et al. 1995).