A recent meta-analysis estimated that breast cancer risk increased by 17% with every 10 cm increase in height52 and endogenous factor such as IGF-1 have been linked to underlying height, MD and breast cancer risk.53,54 However, prior evaluations of MD and height have led conflicting results; positive22,55 and null associations48,50 have been reported in both Asian and Western populations. The gene discussed is IGF1; the disease is breast cancer.